Napakiak is a city in Bethel Census Area, Alaska, United States. At the 2010 census the population was 354, up one resident from 353 since 2000. Napakiak is located at 60°41′36″N 161°58′25″W / 60.69333°N 161.97361°W, on the north bank of the Kuskokwim River, approximately 10 miles downriver of Bethel.