Iran and the U.S. have see-sawed between enmity and grudging diplomacy in the years since, with relations peaking when Tehran made the 2015 nuclear deal with world powers. But Trump unilaterally withdrew America from the accord in 2018, sparking tensions in the Mideast that persist today.

Iran talks has been announced to take place in Italy as tensions loom over negotiations for a new nuclear agreement. Newsweek has contacted the U.S. State Department and the Iranian Foreign Ministry for comment.

Iran's Supreme Leader Ayatollah Ali Khamenei said U.S. demands that Tehran stop enriching uranium are "excessive and outrageous", state media reported, voicing doubts whether talks on a new nuclear deal will succeed.