Structural components of LNP. The mRNA molecule is too large to pass through a cell membrane by free diffusion and carries multiple negative charges, increasing the difficulty of their delivery.

The primary components of LNP–RNA are ionizable lipids, cholesterol, PEGylated lipids, and phospholipids, which together form the nanoparticle, along with the active pharmaceutical ingredient ...

Characterization of lipid components in lipid nanoparticle (LNP) formulations – Application Note AN001928 – an-001928-bt-lipid-components-LNP-an001928-na-en.pdf (SECURED) ...

The LNP–mRNA molar mass ranged from around 10 MDa to 1 GDa, with a weight-average molar mass (M w) of 95.4 ± 2.3 MDa and 269.8 ± 5.1 MDa for Comirnaty and Spikevax, respectively.