This has been facilitated by the generation of an antibody to synthetic Aβ oligomers that specifically identifies a common structure that is present in several different amyloid-prone synthetic ...

Once the antibody binds, the fibril is locked in this state, and further growth is prevented. This finding reveals a promising new approach to stopping Aβ fibril growth and, potentially, slowing ...

As reported March 6 in Nature Medicine, they used spatial transcriptomics to study postmortem tissue from 13 people who had been immunized previously with AN1792—an Aβ vaccine—and from one woman who ...

Sabirnetug is the first humanized monoclonal antibody to demonstrate in AD patients selective target engagement of AβOs, a soluble and highly toxic form of Aβ that accumulates early in AD and is ...

Real-time HS-AFM observation of Aβ fibril growth and the 4396C antibody binding at the fibril end Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...