In the September 25 PNAS online, researchers led by Chris Dealwis at the University of Tennessee in Knoxville published the first crystal structure of a monoclonal antibody to the amyloid-β (Aβ) ...

Moreover, the immune system convincingly reflects the complexity of Aβ structure, with study results showing that the antibodies generated in response to Aβ fibrils are diverse, showing their ...

Their Fab/Aβ structure looked very different from each other. Where the 12A11 captures the peptide in an extended conformation, the 3D6 holds a helical one. Taken together, crystal structures of four ...

Lecanemab is a humanized monoclonal antibody that binds with high affinity to soluble amyloid-beta (Aβ) protofibrils, which have been shown to be more toxic to neurons than monomers or insoluble ...

The study revealed the mechanism by which the 4396C antibody selectively binds to the “paused state” of fibril growth, effectively inhibiting further elongation of Aβ fibrils. A collaborative ...

Now there is a new option. Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to ...

Recent clinical trials demonstrating a slowing of cognitive and functional decline in individuals with AD who are treated with anti-Aβ antibodies reinforce the important role of Aβ in the ...

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden ...