Anti-Aβ antibodies (Aβ-Abs) that bind specific Aβ variants are essential research tools. Furthermore, the monoclonal Aβ-Abs Aducanumab, Lecanemab, and Donanemab have recently gained approval as the ...

which is a non-Aβ specific antibody. This project uses techniques such as fluorescence and multi-dimensional NMR. The second project will determine the Met35 oxidation rates of the Aβ(1-40) and ...

These microglia do respond to anti-Aβ antibodies, regardless of how much TREM2 they express. TREM2 signaling may keep neuronal hyperexcitability in check … somehow. For one, microglia hovering around ...

Once the antibody binds, the fibril is locked in this state, and further growth is prevented. This finding reveals a promising new approach to stopping Aβ fibril growth and, potentially, slowing ...

This authorisation makes the amyloid-beta (Aβ) monoclonal antibody the first to address the underlying cause of Alzheimer's in the European Union (EU). It extends to all 27 member states ...

[13] A phase III trial is underway. Another immunologic strategy involves intravenous immunoglobulin (IVIgG) which contains antibodies against Aβ. These antibodies selectively target Aβ and are ...