CLIMP-63 siRNA transfection enhanced cellular resistance to gentamicin-induced toxicity, which involves apoptosis, in KPT11 cells. Thus, the dimerization of CLIMP-63 is likely an early step in ...

A striking finding in this study was that the immature ear was more susceptible to cochlear damage than the adult’s ear, revealing a sensitive period for aminoglycoside-induced toxicity.

Therapeutic drug monitoring (TDM) in once-daily gentamicin regimens is variable and its role in predicting or preventing clinical toxicity is unclear. We aimed to assess the safety of ODD of ...

Aminoglycoside antibiotics can suppress premature ... owing to gastrointestinal absorption and by severe renal toxicity and ototoxicity at relatively low serum concentrations.

Scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. A new method of ...

This amplified the toxic effects of the drug on the cells. Steyger and his colleagues found that one protein in particular involved in ion channels, TRPV1, facilitated gentamicin’s entry into ...

Administering the dose could increase the risk of toxicity; withholding the dose ... and predict pharmacokinetic parameters. The aminoglycosides have been noted to have two- or even three ...

the quality control machinery was able to eliminate the toxic protein and the cells survived.” The same thing happens, he noted, in cells treated with sublethal doses of aminoglycoside antibiotics.

"We've stopped paying attention to their toxic side effects because living with hearing loss is better than dying." The gentamicin used in hospitals today is a mixture of five different subtypes ...