the quality control machinery was able to eliminate the toxic protein and the cells survived.” The same thing happens, he noted, in cells treated with sublethal doses of aminoglycoside antibiotics.

A striking finding in this study was that the immature ear was more susceptible to cochlear damage than the adult’s ear, revealing a sensitive period for aminoglycoside-induced toxicity.

Scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. A new method of ...

CLIMP-63 siRNA transfection enhanced cellular resistance to gentamicin-induced toxicity, which involves apoptosis, in KPT11 cells. Thus, the dimerization of CLIMP-63 is likely an early step in ...

Therapeutic drug monitoring (TDM) in once-daily gentamicin regimens is variable and its role in predicting or preventing clinical toxicity is unclear. We aimed to assess the safety of ODD of ...