In a Nature Communications paper, the laboratory of Professor Jan Terje Andersen and collaborators report on a novel antibody constant region (Fc) variant that is designed to give antibodies broad ...

The first generation of humanized antibodies - referred to as chimeric antibodies - saw the constant regions of a mouse antibody replaced with those of a human antibody, considerably reducing ...

The scaffold has been developed by incorporating specific amino acid changes in the CH3 region of the constant Fc domain of a native IgG1 class antibody. Zymeworks claims that in addition to ...

Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that ...