Each antibody molecule possesses distinct variable and constant regions. The variable region confers an antibody's antigen-binding specificity. This region contains two fragment antigen binding ...

The first generation of humanized antibodies - referred to as chimeric antibodies - saw the constant regions of a mouse antibody replaced with those of a human antibody, considerably reducing ...

Both heavy and light proteins have constant regions, which are the same or similar among all antibodies produced. They also both have a variable region, which is unique to every antibody.

The scaffold has been developed by incorporating specific amino acid changes in the CH3 region of the constant Fc domain of a native IgG1 class antibody. Zymeworks claims that in addition to ...

Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that ...