This textbook view has been established based on cumulative data obtained primarily using Fab and Fc fragments cleaved from antibody molecules. The collaborative groups including researchers at ...

such that the Fc region moves out of the plane of the antigen-binding (Fab) arms. As the therapeutic use of antibody continues to increase, detailed understanding of effector function sites will ...

Two hinge regions link the Fab and Fc portions of each antibody molecule. There are five main types (isotypes) of antibodies, each with distinct structures and functions: IgG, IgM, IgA ...

portions of antibodies and the Fc receptor on cells, and the ability to engineer the Fab region for improved specificity and therapeutic efficiency. Antibody fragments are commonly produced as ...

Mix and Match. The BBB transport vehicle (left) is an antibody Fc region harboring a domain that binds to the transferrin receptor. The TV can be affixed with antibody Fab regions specific for one or ...

Some of the variability in the development and clinical manifestations of a disease, and ultimately the response to intravenous immune globulin, may relate to differential antibody Fc ...

Highlights of the poster presentation entitled, “S-4321, a novel dual-cell bidirectional PD-1:FcγRIIb selective agonist antibody for the treatment of autoimmune disease,” include ...