Two hinge regions link the Fab and Fc portions of each antibody molecule. There are five main types (isotypes) of antibodies, each with distinct structures and functions: IgG, IgM, IgA ...

Antibodies induce antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity and efficient cross-presentation by APCs through the Fc portion. Novel technologies aiming at ...

This enables preservation of the antigen-binding fragment (Fab) structure of the parental antibody and substitution of the crystallizable fragment (Fc) region with a monovalent variable fragment ...

ADS provides exceptional capabilities in antibody drug discovery ... antibodies comprising fully human Fab and upper hinge regions and mouse middle hinge and Fc regions. Optimized constant domains ...