The slow loss of memory, thinking, and independence that defines Alzheimer’s disease continues to affect millions worldwide.

Some clinical trials for treatments that nip Alzheimer’s disease in the bud rely on recruiting carriers of autosomal-dominant mutations who will develop Alzheimer’s disease in a predictable fashion.

Germline mutations may be “dominant” or “recessive.” In autosomal dominant diseases, one parent has a normal copy of the gene and a mutated copy; there is a 50-50 chance a child will ...

Autosomal dominant single-gene diseases occur in individuals ... to potentially "cancel out" the negative effects of X-linked mutations, they are far more likely than women to be affected by ...

Huntington described the autosomal dominant inheritance pattern of this ... all affected individuals would carry the same original mutation as the founder. Over a period of more than 20 years ...

At the heart of the acquisition is Regulus’ farabursen, an miRNA-targeting oligonucleotide in early-stage development for ...