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Glial cells support neurological structures, function, cognition, behaviours, physical skills, and motor coordination.
The research, reported in Cell Metabolism, is the first to establish a link between glucose metabolism in glial cells and functional regeneration of damaged neurons in the central nervous system.
The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.
Researchers in Philadelphia have found promising results in efforts to treat spinal cord injuries by activating metabolic pathways in glial cells to promote axon regeneration. A new study ...
The glial cells that surround the axons in the olfactory bulb (OBG) are a promising example because they promote axon regeneration in the CNS.
"We found that glia have a metabolic switch associated with glucose metabolism that when triggered reverses inhibitory effects on growth and promotes axon regeneration," explained Shuxin Li, MD ...
Dr. Li and colleagues examined the specific pathway by which lactate and hydroxyglutarate act to enhance axon regeneration. Experiments revealed that when glial cells are activated, they release ...
Here we demonstrate a novel role for Fgf signaling during glial cell morphogenesis in promoting axonal regeneration after spinal cord injury. Zebrafish glia are induced by Fgf signaling, to form an ...
For a long time, the study of axon damage and regeneration in SCI has been constrained by the lack of suitable in vivo imaging tools capable of visualizing undisturbed cellular processes within ...
An overview of proteins that play a crucial role in axon regeneration of retinal ganglion cells under experimental conditions, which may pave the way to restoring axonal tissue after injury.
When a nerve is damaged, glial cells produce the protein neuregulin1 and thereby promote the regeneration of nerve tissue.
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