Once dismissed as “junk,” a group of RNA molecules has been found to help regrow damaged nerves in mice in new research. The ...

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Results of a study performed in mice and published in Cell Metabolism suggest that increasing energy supply within these injured spinal cord nerves could help promote axon regrowth.

Using that technique, the researchers succeeded in controlling the reaction of astrocytes and when the latter were cultured with neurons, they promoted neuronal survival and triggered axonal growth.

The scientists also showed they could encourage axon regrowth in cell cultures and in animals by dosing the cells with drugs that made it easier for HDAC5 to leave the nucleus.

Researchers observed axon regrowth in injured mice that received a single treatment injection of the growth-factor protein, and the animals also regained movement in their hind limbs.

Damage to the spinal cord rarely heals because the injured nerve cells fail to regenerate. The regrowth of their long nerve fibers is hindered by scar tissue and molecular processes inside the ...

“We observed a lot of axon regrowth, which could be very significant clinically since there currently are no regenerative treatments for spinal cord injury or optic nerve injury,” Li noted.

If there is fairly significant axonal loss (decreased nerve conduction amplitude), the EMG should eventually yield increased insertion activity and increased amplitudes of motor units surveyed.

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