This “tripartite” protein complex, also known as a multidrug efflux pump, forms a conduit that drains out not only antibiotics but also virulence factors – i.e., molecules that are produced by the ...

also known as a multidrug efflux pump, forms a conduit that drains out not only antibiotics but also virulence factors—i.e., molecules that are produced by the bacterial cell itself and can ...

TAXIS has developed a novel strategy consisting of targeting bacterial efflux pumps, a family of multi-protein complexes that span the bacterial cell membranes and act like bilge pumps that flush ...

We have identified and developed compounds that act as bacterial efflux pump inhibitors (EPIs). Bacterial efflux is one of the primary mechanisms by which bacteria can develop resistance to current ...

[53] Multidrug resistance due to the expression by bacteria of an efflux pump is an increasing clinical problem. Therefore an interesting approach to the therapy of many infections would be one ...

Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access via porins, they are ...

We conduct antimicrobial discovery research towards mitigating microbial contamination of jet fuel and study bacterial biofilms, solvent resistance mechanisms such as efflux pumps, trace element ...

coli and H. influenzae. AcrB efflux pumps can actively transport antibiotics out of the periplasm and cytoplasm of bacterial cells, rendering them ineffective. AcrB-Ec can also export bile salts ...

For example, structures called "efflux pumps" in the cell membrane allow bacterial cells to pump out antibiotics that get inside the cell. Bacterial cells can also make enzymes that chemically ...