Antibodies are proteins with around 150 kDa molecular weight. They have a similar basic structure comprising of four polypeptide chains held together by disulfide bonds. These four polypeptide ...

The basic pattern of the principal class of molecules that neutralize antigens (foreign substances in the body) is four cross-linked chains. This pattern is modified so that antibodies can fit ...

However, the basic chemical structure of antibodies had been already determined during the previous decade, in particular thanks to the works of Rodney Porter and Gerald Edelman. Understanding the ...

The structure of the 2G12 antibody could provide scientists with ... to pursue AIDS treatments and prevention." NIGMS supports basic biomedical research that lays the foundation for advances ...

However, emerging non-traditional antibody formats are more efficacious and capable of reaching new targets, including crossing the blood–brain barrier. Formats that retain the basic structure ...

What was known, however, is that the structure between the antibody arms, the so called hinges, changes over time. This latest research harnesses this property of the hinge and explains how it ...

A research team led by a Duke professor recently developed a novel computational model to predict antibody structures, a significant breakthrough for disease prevention efforts. A study published ...

1 The basic mechanism involves monoclonal antibodies affixing themselves to ... 4 This article considers the structure, mechanism of action, and evolution of three generations, clinical success ...