In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the ...

The team also demonstrates the key role of gamma ... beta-actin filaments. "This result is particularly interesting because the stiffness of the apical membrane is essential for auditory function ...

In unstimulated cells, the state of G alpha (orange circles) is defined by its interaction with GDP, G beta-gamma (purple circles), and a G-protein-coupled receptor (GPCR; light green loops).