Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block results ...

Hematopoietic stem cells (HSCs) can differentiate into any blood cell. However, as HSCs age, they are more likely to ...

A comprehensive, large-scale analysis has been needed to reveal how cell development in AML is altered to support more ...

A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in ...

These events are associated with innate training and can have long-term impacts on hematopoietic stem and progenitor cell (HSPC) development but can also compromise their function. While many ...

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological ...

Multiple cell therapies deliver exogenous bone marrow stem cells into patients, which may trigger body repair machinery or regulate the endogenous stem cell population to achieve tissue homeostasis ...

A total of 263,159 single-cell transcriptomes were collected from bone marrow samples of 45 healthy ... states were grouped into 13 broader differentiation states to enable comparative analysis ...

Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block ...