A Cas protein binding can't be too transient, according to Porter Hall, a biophysics doctoral candidate in the Wang Lab and the lead author of the publication.

The CRISPR-Cas system is a powerful gene-editing tool widely used in bacteria and archaea to defend against the invasion of foreign DNA. To balance this potent defense mechanism, some bacteria and ...

“We describe a minimal functional CRISPR-Cas system, comprising a single ~70-kilodalton protein, CasΦ, and a CRISPR array, encoded exclusively in the genomes of huge bacteriophages,” the ...

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them ...

Hypercompact Cas protein should allow easier viral delivery of gene editors Date: July 16, 2020 Source: University of California - Berkeley Summary: ...

Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function.

We showed that the Cas protein forms a binary complex with guide RNA and remains bound when it interacts with target DNA – subsequently forming a ternary complex. Overall, our results reveal the ...

The team then trained their ProGen2 language model—which was fine-tuned for protein discovery—using the CRISPR atlas. The AI eventually generated four million protein sequences with potential Cas ...

With the first medical therapy approved and systems like CRISPR-Cas showing up in complex cells, there’s a lot happening in the genome editing field.

A Cas protein binding can't be too transient, according to Porter Hall, a biophysics doctoral candidate in the Wang Lab and the lead author of the publication.