Brain organoids are typically grown in culture ... Additionally, they found that a molecule called CD38 was crucial in mediating metabolic and energetic stress in those reactive astrocytes.

At present, the most widely researched monoclonal antibody for MM targets CD38. However, newer developments of bispecific antibodies that target CD38/CD3 are in the pipeline – taking full ...

Peripheral sensory neuropathy: damage to the nerves outside of the brain and spinal cord ... Darzalex, according to the National Cancer Institute, binds to the protein CD38 found on some types of ...

brain activation during emotion recognition tasks, responses to trauma, and the risk of autism. Recently, researchers have identified that A allele carriers of the CD38 single nucleotide ...

However, IFNy also stimulates CD38, a protein that suppresses the immune cells' ability to mount a response against infection. To overcome this challenge, the researchers designed a T cell engager ...

she said. To uncover the molecular mechanisms regulating ovarian NAD+ loss, first the researchers began by adding another piece of the puzzle: CD38, an enzyme known to be one of the main culprits ...

CD38 is an enzyme with NAD-depleting and intracellular signaling activity expressed on the cell surface, in intracellular compartments and in mitochondria, and is linked to inflammatory and autoimmune ...

Johnson & Johnson is dropping a partnership with Genmab centered around a CD38 monoclonal antibody, prompting the latter company to discontinue development of the program. Back in 2019 ...

While the initial HexaBody-CD38 clinical data is promising and showed robust clinical efficacy, following a thorough evaluation of the data, the market landscape, and Genmab’s rigorous portfolio ...

"These data further our understanding of the role of CD38 + antibody secreting cells in IgA nephropathy pathogenesis," said corresponding author Millie Shah, Ph.D., Senior Scientist at Biogen.