“When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8+ T cells,” Grimson said. Meanwhile, in Hanson’s lab, ...

If CD8+ T cell exhaustion can be reversed, the next question is whether such reversal actually benefits a patient, as exhaustion can have protective qualities.

"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...

A pair of recent studies from the laboratory of Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology, have ...

Silencing KLF2 drove the CD8 T cells along a different path, directing them away from becoming killer cells and toward a ...

This altered metabolism resulted in increased levels of lipid peroxides and potentiated the metabolic and functional exhaustion of CD8 + T cells in cancer. Chronic type I interferon signaling ...

Cannabis and its synthetic cannabinoids have been studied for medicinal properties across multiple d Researchers evaluated the effect of cannabis on inflammation, immune function, and the HIV ...

Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study ...