"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...

If CD8+ T cell exhaustion can be reversed, the next question is whether such reversal actually benefits a patient, as exhaustion can have protective qualities.

This altered metabolism resulted in increased levels of lipid peroxides and potentiated the metabolic and functional exhaustion of CD8 + T cells in cancer. Chronic type I interferon signaling ...

Like much of Dr. Xue's other work, the latest paper focuses on CD8 + T cells ... these effector cells eventually enter a state of "exhaustion" which makes them less and less effective.

“When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8+ T cells,” Grimson said. Meanwhile, in Hanson’s lab, ...

Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...

Their study demonstrated that prolonged antigen stimulation in vitro caused upregulation of key exhaustion markers—PD-1, LAG-3, TIM-3, TIGIT, and CD39—on both CD4+ and CD8+ T cells. These markers were ...

Silencing KLF2 drove the CD8 T cells along a different path, directing them away from becoming killer cells and toward a ...

A pair of recent studies from the laboratory of Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology, have ...