Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a ...

With a few exceptions, eukaryotic chromosomes have a single centromere that ensures their accurate segregation during mitosis. Chromosomes that lack centromeres segregate randomly during mitosis ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of the cell. Cells with an abnormal number of chromosomes consequently ...

In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a cellular machine composed of microtubules and their associated proteins. Spindles are built from ...

Among the many marvels of life is the cell’s ability to divide and thus enable organisms to grow and renew themselves.

Timelapse of chromosome segregation in a larger fish embryo Close-up timelapse of chromosome segregation in an early fish embryo ...

We usually think of the chromosome segregation machinery as ensuring unbiased, random segregation. As we learn in high school biology, if a diploid individual carries two different alleles of a gene ...

This figure depicts chromosome segregation errors in meiosis. (A) The three main classes of segregation errors. (B) Incorrect alignment of chromosome kinetochores (C) Mitotic spindle errors.

Unlike cancer cells, normal cells do not tolerate errors in chromosome segregation. This finding, which we published in Nature in 2018, suggested that the act of being unstable is itself critically ...

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation (Meiosis I and Meiosis II respectively). In Meiosis I homologous chromosomes separate, which ...

In fact, mutations in condensin structure can result in severe chromosome segregation defects and lead to cell death, cancer formation, or rare developmental disorders called 'condensinopathies'.