These kinetochores are responsible for the attachment of spindle microtubules, which enable chromosome congression and proper segregation during cell division. Defects in the structure or function ...

With a few exceptions, eukaryotic chromosomes have a single centromere that ensures their accurate segregation during mitosis. Chromosomes that lack centromeres segregate randomly during mitosis ...

Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important ...

In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a cellular machine composed of microtubules and their associated proteins. Spindles are built from ...

We usually think of the chromosome segregation machinery as ensuring unbiased, random segregation. As we learn in high school biology, if a diploid individual carries two different alleles of a gene ...

This figure depicts chromosome segregation errors in meiosis. (A) The three main classes of segregation errors. (B) Incorrect alignment of chromosome kinetochores (C) Mitotic spindle errors.

(B) In meiosis, two chromosome-segregation phases, meiosis I and meiosis II, follow a single round of DNA replication during the premeiotic S phase. During meiosis I, homologous chromosomes (shown ...

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation (Meiosis I and Meiosis II respectively). In Meiosis I homologous chromosomes separate, which ...

Timelapse of chromosome segregation in a larger fish embryo Close-up timelapse of chromosome segregation in an early fish embryo ...

Unlike cancer cells, normal cells do not tolerate errors in chromosome segregation. This finding, which we published in Nature in 2018, suggested that the act of being unstable is itself critically ...

My research focuses on the segregation of chromosomes during cell division. Chromosomes are the bodies that contain our DNA and it’s critical that each cell has the correct DNA in the correct quantity ...

In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer. Joan Massagué, PhD Joan Massagué studies the control of stem ...