Dapagliflozin reduced the risk of all-cause mortality or worsening heart failure by 28% in patients with aortic stenosis ...

Dapagliflozin as Monotherapy ... achieved statistically significant mean reductions at 5 mg and 10 mg doses once daily in the primary ... (LSN, NYSE: AZN) as a once-daily oral therapy for ...

On average, dapagliflozin doses of 5 or 10 mg daily can lead to the excretion of approximately 70 grams of glucose per day after 12 weeks of treatment, with near-maximum glucose excretion observed ...

Within 24 hours of hospitalization, participants were randomly assigned to dapagliflozin 10 mg once daily or structured usual care with protocolized diuretic titration until day 5 or hospital ...

However, in this study, dapagliflozin was administered at either 5 mg or 10 mg. The results showed that 87.7% of patients in the dapagliflozin group received 5 mg at the end of the 2-year ...

In the study, at 24 weeks, the 271 patients assigned to dapagliflozin 5 mg daily achieved a 0.37% decline in HbA1c; the 270 patients assigned to dapagliflozin 10 mg daily achieved a 0.42% decline ...

At the last assessment, 2039 of the patients who were still taking dapagliflozin (98.1%) continued to receive the 10-mg daily dose; 1993 patients (98.2%) were receiving the equivalent dose of placebo.

Dapagliflozin provided significant reductions in HbA1c, total daily insulin dose, and body weight in type 1 diabetes and was well tolerated, with no new safety signals, in a 24-week trial.

Bristol-Myers Squibb and AstraZeneca announced positive results from a Phase 3 study of dapagliflozin as add-on therapy to metformin for the treatment of type 2 diabetes. This 24-week, randomized ...

ADA 70th Scientific Sessions ORLANDO — Dapagliflozin, an investigational selective sodium-glucose cotransporter-2 inhibitor, improved HbA1c levels and induced further weight loss in combination ...

In the ROTATE-3 crossover trial, investigators randomly assigned 46 patients to 3 consecutive 4-week treatments of dapagliflozin 10 mg once daily, eplerenone 50 mg once daily, or a combination of ...

Individuals treated with dapagliflozin also demonstrated a reduction in daily insulin dose at week 24: -1.80 IU/d for dapagliflozin 2.5 mg, -0.61 IU/d for dapagliflozin 5 mg and -1.16 IU/d for ...