Demethylation reactions were conducted with 2 μl of the immobilized anti-FLAG bead suspension with peptide (10 μM) and cofactors/substrates (conditions given in Supplementary Table 3).

SALL4 up-regulation after treatment with hypomethylating agents was observed in 10 of 25 patients (40%) in cohort 1 and in 13 of 43 patients (30%) in cohort 2 and was associated with a worse ...

Looking at prior research data, the team found that as tomatoes became more domesticated over the past few centuries, ...

Reversing this modification requires DNA demethylation, a series of enzymatic reactions which starts with the creation of 5-hydroxymethylcytosine (5hmC).

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide. Nature Structural & Molecular Biology , 2025; DOI ...

Post-translational gene expression is regulated by ALKBH1, an enzyme that demethylates transfer RNA.

Lochmann TL, Powell KM, Ham J, et al. Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma. Sci Transl Med 2018;10(441):eaao4680-eaao4680.

Mechanism behind demethylation pinpointed in APC gene mutants. ScienceDaily . Retrieved May 24, 2025 from www.sciencedaily.com / releases / 2010 / 09 / 100917183031.htm ...

Methylation-specific polymerase chain reaction, bisulfite genomic sequencing, and immunohistochemistry were used to assess demethylation and gene re-expression. Results. Substantial degrees of ...

Methylation-specific polymerase chain reaction, bisulfite genomic sequencing, and immunohistochemistry were used to assess demethylation and gene re-expression. Results. Substantial degrees of ...