The regenerative response initiated following axonal injury ... ‘orchestrator of gene regulation’ epigenetic changes would direct expression of genes crucial for regeneration only in the ...

Cho et al., “Injury-induced HDAC5 nuclear export is essential for axon regeneration,” Cell, 155:894–908, 2013. To regenerate after injury, a nerve cell must turn on gene programs that have been ...

Researchers used a small molecule called TTK21 to activate genetic programming that induces axon (nerve fibre) regeneration in neurons. TTK21 changes the epigenetic state of genes by activating the ...

Building on their past success, researchers used a small molecule called TTK21 to activate genetic programming that induces axon regeneration in neurons. TTK21 changes the epigenetic state of ...

The team also developed machine-learning algorithms which demonstrated that the epigenetic markers go ... reveals that if we want to promote axonal regeneration, we need to find tools to 'open ...

In contrast, there was no evidence of axonal regeneration when expression of ... ganglion cells treated with OSK showed reversal of epigenetic changes associated with aging. The so-called ...

During muscle regeneration, a natural response to injury ... the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative ...

Overall, the process involved the down-regulation of transcriptional regulation ... highlighting the potential implications of Kla in cardiac regeneration and aging. Through multi-omics analysis ...

The groundbreaking study grew out of Wang's desire to better understand the epigenetic regulation of stem cell ... therapeutic targets in tissue regeneration and treatment for osteoporosis." ...