People with darker skin tones are less likely to have the FLG gene mutation and are more likely to have mutations in the FLG2 gene, which plays a role in the skin barrier's function and can lead ...

The discovery of the association of FLG mutations with atopic diseases followed insights into a common disorder of keratinization, ichthyosis vulgaris. The epidermis of individuals with AD shows a ...

The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an ...