Data shows how antibodies bind to V1/V2 domain. Scientists report on the structure of the HIV-1 gp120 glycoprotein’s V1/V2 domain and how a broadly neutralizing antibody binds to the structure ...

REVELATION: The glycoprotein gp120 binds to the CD4 receptor on the T cell, causing the viral molecule to contort in a way that enables it to bind to the nearby chemokine receptor, too. This dual ...

Kwong, P. D. et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393, 648–659 (1998).

HIV-1 glycoprotein 120 (gp120) is known to cause neurotoxicity via several mechanisms including production of proinflammatory cytokines/chemokines and oxidative stress. Likewise, drug abuse is ...

Further assays using anti-gp120 antibodies indicated that the chemokine binds to a region on the outer surface of the gp120 glycoprotein that is near to but doesn’t overlap the CD4 binding site.

(Cited in 67 papers) The finding: Using X-ray crystallography, researchers at Harvard Medical School, led by Stephen Harrison, determined the structure, at 4 Å resolution, of the un-bound simian ...

Called gp120, it might be the vaccine that prevents AIDS. If gp120 succeeds, it will be because one man, Dr. Donald Francis, wouldn't let it die. Gp120 has powerful enemies.

A glycoprotein on the HIV envelope. gp120 binds to a CD4 receptor on a host cell, such as a CD4 T lymphocyte (CD4 cell). This starts the process by which HIV fuses its viral membrane with the host ...

Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120–MF59 in Adults. 2021-03-25. DOI: 10.1056/NEJMdo006028. Save. Permissions.