The phosphoribosyltransferases (PRTases) are involved in purine, pyrimidine and amino acid synthesis 3. Structures of several type I PRTases reveal a common α/β-fold called the PRPP motif and ...

The condition occurs due to issues with the enzyme known as hypoxanthine-guanine phosphoribosyltransferase (HPRT), which results in the accumulation of uric acid. Lesch-Nyhan syndrome is an X ...

Lesch-Nyhan syndrome is a rare X-linked genetic disorder caused by a deficiency in the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This enzyme is involved in purine salvage, and its ...