The structure of CL4F 8-6, the branched ionizable lipid that was most effective in increasing storage stability and LNP-RNA delivery (Image: Yusuke Sato).

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as a genetic instruction book, telling cells to produce therapeutic or ...

LNPs can carry gene editing machinery like Cas9 mRNA or guide RNA into cells. This opens the ability for LNPs to be used as a delivery system for gene therapy. At the moment, there is an LNP-based ...

CPD-accredited course delivered in an engaging way by our incredible RNA and LNP experts with videos and animation. There's also the opportunity to ask any burning questions in a dedicated Q&A session ...

PNI’s lipid nanoparticles (LNPs) protect the RNA payload and release it into the interior of the target cell through receptor-mediated endocytosis. PNI’s proprietary library of LNP ...

In individual sub-projects, various issues relating to the production, formulation and stabilization of RNA in liquid nanoparticles, so-called LNP-RNA, are being investigated. The joint project is ...

PNI’s lipid nanoparticles (LNPs) protect the RNA payload and release it into the interior of the target cell through receptor-mediated endocytosis. PNI’s proprietary library of LNP ...