In mutated lymphocytes, the microtubules making up the cytoskeleton are disorganized and there are fewer adhesion proteins. The cells lose their polarity and their 'muscles'." ...

Lymphocytes are a group of white blood cells that help your body fight off disease. Most laboratories define lymphocytosis as a lymphocyte count of over 3 to 4 billion cells per liter of blood.

However, they may need to undergo regular blood testing so that doctors can monitor their lymphocyte count. This is because some people with MBL can develop other B-cell diseases, such as CLL.

HIV infection profoundly disrupts the immune system. HIV infection targets the CD4+ T lymphocytes that are the cells responsible for regulating both the humoral and cell-mediated immune systems ...

In the second screen, Jurkat T lymphocytes were co-cultured with PD-1-expressing cells for 60 hours and then stimulated with anti-CD23 and anti-CD28 antibodies for 12 hours.

Here, we developed in silico structure-based prediction of neoantigen discovery pipeline by pairing with T cell receptors (TCRs) on pre-existing CD8+ exhausted tumor-infiltrating lymphocytes. Methods: ...

Lymphoproliferative disorders are a group of diseases that cause an uncontrolled production of lymphocytes, a type of white blood cell. Examples include non-Hodgkin’s lymphoma and certain leukemias.