They identified two distinct modes of endosomal fusion: homotypic fusion, where two endosomes fuse rapidly to form a single ...

were the first to suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar 1966). Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore.

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The autolysosome ultimately matures into a lysosome, where the waste is ...

We found that Rab7, a protein present on the MVB’s outer membrane, is a regulator involved in dictating the fate of the vesicles. We believe that active Rab7 directs the EV toward the lysosomes, but ...

According to biology textbooks, a macrophage engulfs a bacterium, internalizes it in a toxin-filled vesicle called a phagosome, then shuttles the cellular remains to a lysosome for degradation. But ...

Questions to consider: How is vesicle formation and transport included in the model ... bound organelles Endosome transport from the Golgi or Plasma Membrane to the Lysosome Using animated or active ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...