Tetracyclines inhibit synthesis of proteins by binding to the 30S ribosome subunit but have a different method of action to aminoglycosides. Instead of preventing proof-reading of the peptide ...

In a paper just published in the journal PLOS ONE, the scientists describe how this erroneously built protein mimics the action ... with aminoglycosides. That gives us a way to study the mechanism ...

Aminoglycoside antibiotics (AGAs ... based on differences in the site of sugar attachment. The mechanisms of action of kasugamycin and validamycin differ from those of clinical AGAs.

Aminoglycosides can override the stop signal ... and the study revealed a novel mechanism through which future drugs could potentially override the erroneous stop signal. The next step is to ...

An international team of researchers, including scientists of the University of Groningen, has now demonstrated how the antimalarial drug mefloquine can enhance the effect of aminoglycosides ... the ...