Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed single-cell atlas of ...

Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block results ...

Hematopoietic stem cells (HSCs) can differentiate into any blood cell. However, as HSCs age, they are more likely to ...

A new single-cell reference atlas of normal hematopoiesis has helped researchers identify novel acute myeloid leukemia cell ...

Researchers have developed a map of normal hematopoietic cell differentiation and used it to examine how aberrant differentiation can lead to #AML, according to results presented by Andy Zeng, PhD, at ...

TREMs define the threshold and duration of myeloid cell responses, both promoting and attenuating myeloid cell activation and differentiation. 1 To that end, TREMs have been implicated in numerous ...

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological ...

Scientists from the University of Tokyo have identified a key aging marker for hematopoietic stem cells (HSCs), shedding light on how these cells undergo changes over time. Cluste ...

Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block ...

Get Instant Summarized Text (Gist) A novel combination therapy shows promise in treating acute myelogenous leukemia (AML) by overcoming the differentiation blockade in myeloid progenitor cells ...