Renal carcinoma cells are invading the bone marrow, and osteoclasts (arrows) are actively resorbing bone adjacent to the tumor cells. Panel C shows osteoblastic metastasis (hematoxylin and eosin ...

In 2003, Schwarz and team guessed that osteoclast precursors must come from the bone marrow near affected joints. In the human embryo, one layer of stem cells develops into the common source of ...

Special cells called osteoclasts break down old bone ... But confirmation of the diagnosis requires a bone marrow biopsy to get tissue. A biopsy is the most common test used to diagnose lesions ...

A culture of murine bone marrow-derived macrophages was incubated with RANKL and M-CSF, vital for osteoclast precursor differentiation to functionally active osteoclasts. 1,5 Melatonin was applied ...

By employing cutting-edge single-cell RNA sequencing on bone marrow from a mouse model of ... to have reduced potential for transforming into osteoclasts—the cells responsible for bone resorption.

(B) The mechanism of osteoclast precursor cell differentiation inhibition and the mechanism of bone marrow cells secreting related inflammatory factors to further inhibit osteoclast differentiation.

A protein — RANK ligand, or RANK-L — stimulates osteoclasts to break down bone ... the cancerous cells interact with the bone marrow microenvironment in a way that leads to increased ...

These conditions often result from the dysregulation of osteoclasts—specialized cells responsible for breaking down bone tissue. Today, many promising treatments target the receptor activator of ...

Multiple myeloma is a bone marrow cancer that affects a person ... Two kinds of bone cells work together to keep bones healthy: osteoclasts and osteoblasts. Osteoclasts are cells in the body ...