The specification of T-helper-cell subsets is controlled by networks of lineage-specifying transcription factors, which bind to regulatory elements in genes that encode cytokines and other ...

The cytokine environment during priming and the consequent activation of specific transcription factors are two key elements controlling Th cell differentiation from naïve CD4 T cells.

Helper T cells (T H cells) are essential in generating an immune response. They secrete signaling molecules called cytokines that activate antibody-producing B cells and other T cells (T C cells ...

A new model to study T cell exhaustion Several years ago, Obst developed an animal model which has now yielded important insights. He focused on T helper cells, which express the CD4 marker ...

Seven STATs have been identified, but STAT5 is of particular interest because it is involved in crucial cellular signaling and plays a key role in helper T cell growth and expansion. The STAT5 ...

T cells are immune cells with multiple functions. There are also subpopulations of T cells with specific functions to aid immunity. T helper cells are one subpopulation that indirectly activates T ...

The cytokine profile (including key cytokine receptors as denoted by R), the effector cell type that is activated, and the corresponding types of infections are shown for each Th subgroup.

HOUSTON - Expression of a single gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases ...

The research indicates that reprogrammed T helper cells adopt characteristics of a new T helper cell type while preserving some of their original traits, making them “super powerful and potent ...

Current research suggests that T helper-type 1 (Th1) cells, previously thought to mediate autoimmunity, may actual inhibit the development of experimental immune encephalomyelitis (EAE), a mouse ...

They found that a specific type of immune cell, called T follicular helper cells, indirectly controls the anti-influenza response. These helper cells often 'see' the wrong parts of the virus ...

Different T cells perform different functions in this process. So-called T helper cells secrete cytokines that attract other immune cells to the site of infection and trigger inflammation there.