siRNA oligonucleotides (p400 no. 1 and no. 2, VHL smart pool, Rb smart pool, p53 smart pool, p27 smart pool and Skp2 smart pool) were obtained from Dharmacon and transfected with Oligofectamine ...

Although a person is born with it, symptoms tend to appear in young adulthood. While VHL syndrome usually causes benign cysts, the tumors can sometimes be cancerous. In fact, people with VHL ...

This makes them impossible to predict. Recurring hemangioblastomas may signal an underlying genetic condition such as von Hippel-Lindau (VHL) disease. A hemangioblastoma occurs as a result of VHL.

Despite the gains, many questions remain. VHL is a cancer syndrome characterized by highly vascularized tumors, such as hemangioblastomas and clear cell carcinomas. Those with von Hippel-Lindau ...

The patient’s height was 3 SD below the population mean for his age and sex. The patient’s systolic blood pressure was 2 SD below the mean for his age and sex; his diastolic blood pressure was ...

WELIREG was approved in the US in August 2021 for similar indications. The open-label trial enrolled 61 subjects with VHL-associated RCC and demonstrated an ORR of 49% with all responses being ...

Welireg (belzutifan), an oral HIF-2 alpha inhibitor, has been approved by the FDA for adults with von Hippel-Lindau (VHL) disease, an inherited condition caused by a mutation in the VHL gene that ...

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction. Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-21258-5 Cite This Page : ...