Reovirus infection was able to reduce HIF-1α levels in both von Hippel Lindau (VHL)−/− renal carcinoma A498 and p53−/− HCT116 cells, indicating that the decrease of HIF-1α mediated by ...

This motif, or stretch of amino acids, normally enables LANA to bind to tumor suppressors p53 or VHL, thus bringing them into the active ubiquitylation complex. Once in the complex, the tumor ...

Although a person is born with it, symptoms tend to appear in young adulthood. While VHL syndrome usually causes benign cysts, the tumors can sometimes be cancerous. In fact, people with VHL ...

Despite the gains, many questions remain. VHL is a cancer syndrome characterized by highly vascularized tumors, such as hemangioblastomas and clear cell carcinomas. Those with von Hippel-Lindau ...

This makes them impossible to predict. Recurring hemangioblastomas may signal an underlying genetic condition such as von Hippel-Lindau (VHL) disease. A hemangioblastoma occurs as a result of VHL.

WELIREG was approved in the US in August 2021 for similar indications. The open-label trial enrolled 61 subjects with VHL-associated RCC and demonstrated an ORR of 49% with all responses being ...

The patient’s height was 3 SD below the population mean for his age and sex. The patient’s systolic blood pressure was 2 SD below the mean for his age and sex; his diastolic blood pressure was ...

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction. Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-21258-5 Cite This Page : ...