The blood-clotting disorder hemophilia A is one of several single-gene diseases that exhibit an X chromosome-linked recessive pattern of inheritance. Males who have a mutant copy of the factor ...

Females (XX) carry twice as many X-linked genes on their sex chromosomes as males (XY). How do cells control gene expression to manage this potentially lethal dosage problem? A prime example of X ...

A new study published in Genetics in Medicine identifies a novel disease-associated gene, GPKOW, that plays an important role ...

The U-M team found a unique solution, moving the X-linked Slxl1/Slx and Y-linked Sly gene families from mouse and putting them into yeast. "We introduced each player in the competition into yeast ...