The nearly 200 countries meeting in Colombia for the United Nations COP16 summit must act urgently to mobilize billions of dollars to stop rapid nature destruction, U.N. leaders and national representatives urged as the talks opened on Monday.

Countries and companies meeting in Cali face tough questions over funding for biodiversity, indigenous rights and who pays for nature’s genetic bounty.

Countries are expected to submit those national biodiversity plans, known as NBSAPs, by the start of the Cali summit that runs from Oct. 21 to Nov. 1. Delegates will use the submissions to gauge how much progress has been made since the COP15 summit in 2022 and what needs to be prioritized going forward.