LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to the ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

First, PINK1 senses mitochondrial damage. Then, it attaches to damaged mitochondria. Once attached, it links to a protein ...

“PINK1 senses this damage and docks to the surface of mitochondria. Once positioned on the mitochondrial surface, PINK1 becomes active and seeks out a small protein known as ubiquitin and marks it.

Researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery. In a major breakthrough, they have been able to see the human PINK1 protein and ...

PINK1 is the second most commonly mutated gene in autosomal recessive Parkinson's disease (PD). The PINK1 gene encodes a 581 amino acid serine–threonine kinase, which is cleaved at its N ...

14 Mar 2025. A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, ...

Scientists have finally pinned down a protein that’s largely responsible for Parkinson’s disease. Known as PINK1, the protein has been linked to the disease for decades but its structure and ...

PINK1 docks onto the surface of damaged mitochondria, becomes activated, and marks them with ubiquitin, this tagging initiates the clean-up process, ensuring that damaged mitochondria do not harm ...

First discovered in 2001, the protein PINK1 has been directly linked to Parkinson’s disease.However, until now, scientists had been unable to visualize human PINK1 or understand how it is switched on ...

The PINK1 ubiquitin signal is unique to damaged mitochondria, and when PINK1 is mutated in patients, broken mitochondria accumulate in cells. Although PINK1 has been linked to Parkinson’s, and in ...