LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to the ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

First, PINK1 senses mitochondrial damage. Then, it attaches to damaged mitochondria. Once attached, it links to a protein ...

PINK1 is the second most commonly mutated gene in autosomal recessive Parkinson's disease (PD). The PINK1 gene encodes a 581 amino acid serine–threonine kinase, which is cleaved at its N ...

Researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery. In a major breakthrough, they have been able to see the human PINK1 protein and ...

14 Mar 2025. A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, ...

“PINK1 senses this damage and docks to the surface of mitochondria. Once positioned on the mitochondrial surface, PINK1 becomes active and seeks out a small protein known as ubiquitin and marks it.

Scientists have finally pinned down a protein that’s largely responsible for Parkinson’s disease. Known as PINK1, the protein has been linked to the disease for decades but its structure and ...

PINK1 docks onto the surface of damaged mitochondria, becomes activated, and marks them with ubiquitin, this tagging initiates the clean-up process, ensuring that damaged mitochondria do not harm ...

PINK1 has therefore been suggested as a potential therapy for those with Parkinson’s for a long time, but this was hard to do because we didn’t really understand how it did its job.

In Parkinson’s disease, mutations in PINK1 and Parkin can result in the accumulation of damaged mitochondria in the brain, leading to the tremors and stiffness that are the hallmarks of the ...