miRNAs are known to target key proteins in the TLR and RIG-I signaling pathways, and like their regulatory protein counterparts, are also involved in the extensive network of inflammatory responses.

BCR enhances the TLR-dependent canonical NF-κB pathway, likely through TRAF6 activation, and TLR enhances the BCR-activated non-canonical NF-κB pathway by inducing p100 expression, thereby ...

We discovered a negative regulator for IL-1R-TLR signaling, the single immunoglobulin IL-1 receptor-related molecule (SIGIRR). We continue to investigate the detailed molecular mechanisms by which ...