In many genetic diseases, a small error in the DNA code can have devastating effects. These errors, called nonsense mutations ...

This causes ion channels in the sensory hair cells of the inner ear to become more permeable to the antibiotics – known as aminoglycosides – which then increases the cells’ sensitivity to ...

The condition’s underlying causes are unclear but may include ... researchers to assess how common it is as a side effect of aminoglycosides. Chemotherapy drugs target and kill different types ...

Aminoglycosides for nearly a century have ... it has been reported to cause hair cell death and subsequent permanent hearing loss among 20-47% of patients, but the underlying mechanisms are ...

Aminoglycosides (and capreomycin) can also affect the loop of Henle and lead to a Bartter-like syndrome. In the collecting ducts, antibiotics can cause a diverse range of disorders, including ...

Aminoglycosides are a class of antibiotics used to treat serious infections caused by bacteria that are difficult to treat. Aminoglycosides are called bactericidal antibiotics because they kill ...

They’re sometimes administered via injection. In some instances, aminoglycoside antibiotics may cause permanent tinnitus. Hearing loss has also been reported. A family history of this condition ...

The researchers found two specific aminoglycoside antibiotics -- Gentamicin ... the antibiotics' effects on mice with the mutation that causes frontotemporal dementia, Zhu says.

Taken together, these data indicate that the metabolic stimuli bolster a process that is specific to aminoglycosides and do not cause persisters to revert to normally growing cells. Figure 2 ...

An international team of researchers, including scientists of the University of Groningen, have now demonstrated how the antimalarial drug mefloquine can enhance the effect of aminoglycosides ...

gene containing a premature termination signal cause a deficiency or absence of functional chloride-channel activity. Aminoglycoside antibiotics can suppress premature termination codons ...