CLIMP-63 siRNA transfection enhanced cellular resistance to gentamicin-induced toxicity, which involves apoptosis, in KPT11 cells. Thus, the dimerization of CLIMP-63 is likely an early step in ...

A striking finding in this study was that the immature ear was more susceptible to cochlear damage than the adult’s ear, revealing a sensitive period for aminoglycoside-induced toxicity.

Therapeutic drug monitoring (TDM) in once-daily gentamicin regimens is variable and its role in predicting or preventing clinical toxicity is unclear. We aimed to assess the safety of ODD of ...

This amplified the toxic effects of the drug on the cells. Steyger and his colleagues found that one protein in particular involved in ion channels, TRPV1, facilitated gentamicin’s entry into ...

Scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. A new method of ...

the quality control machinery was able to eliminate the toxic protein and the cells survived.” The same thing happens, he noted, in cells treated with sublethal doses of aminoglycoside antibiotics.

"Despite these promising results, the most serious problem with aminoglycosides is their toxicity to the kidney and to the inner ear, which causes limitation in their use", says Ms Rebibo Sabbah.

Administering the dose could increase the risk of toxicity; withholding the dose ... and predict pharmacokinetic parameters. The aminoglycosides have been noted to have two- or even three ...

Reformulation and improved purification of the popular antibiotic gentamicin would reduce the risk that it will cause deafness, researchers say. U.S. hospitals use gentamicin to treat a variety of ...

Aminoglycosides are a class of antibiotics used to treat serious infections caused by bacteria that are difficult to treat. Aminoglycosides are called bactericidal antibiotics because they kill ...

"We've stopped paying attention to their toxic side effects because living with hearing loss is better than dying." The gentamicin used in hospitals today is a mixture of five different subtypes ...

"We've stopped paying attention to their toxic side effects because living with hearing loss is better than dying." The gentamicin used in hospitals today is a mixture of five different subtypes ...