In 1955, Squibb received one of the most respected science prizes in the world, the Lasker Award, for its work discovering the antitubercular properties of Nydrazid (isoniazid), an antibiotic used ...

SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous ...

Tuberculosis is the leading cause of infectious disease mortality in the world by a bacterial pathogen. We previously demonstrated that a bisubstrate inhibitor of the adenylation enzyme MbtA, which is ...

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized ...

Phenytoin is one of the most used antiepileptic drugs. Isoniazid, a first-line antitubercular drug, blocks the CYP2C19 enzyme, preventing phenytoin from being metabolised. Concomitant use of phenytoin ...

ARTICLE. Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase: implications to function-based antitubercular agent design. Igor B. Vasconcelos; Luiz A.

Antitubercular activity of water-insoluble ilamycin. J. Antibiot. B 16, 93–98 (1963). CAS PubMed Google Scholar Gao, W. et al. The cyclic peptide Ecumicin ...