Get Instant Summarized Text (Gist) A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been identified, and the complete structure of this pump has been mapped.

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the antibiotic bedaquiline was introduced in 2012, it was the first new tuberculosis ...

Multidrug resistance in Gram-negative bacteria represents a major public health challenge, with these organisms evolving a myriad of mechanisms to evade the effects of antibiotic treatment.

The pumps secrete mycobactin molecules that then tightly bind external iron. The microbial pathogen then uses other molecular machinery to carry the mycobactins and their iron cargoes back into the ...

Discover how antibiotic resistance is transforming routine infections into deadly threats. Learn the shocking truth about 10 ...

Unfortunately, overexpressed MmpL5 can also pump out bedaquiline — the first new turberculosis drug in over 40 years — making the bacteria drug-resistant. Diabling the efflux transporter of M ...

Researchers from King's College London have called for urgent changes to the way new antibiotics are developed to address the growing problem of antimicrobial resistance (AMR).

We have identified and developed compounds that act as bacterial efflux pump inhibitors (EPIs). Bacterial efflux is one of the primary mechanisms by which bacteria can develop resistance to current ...

According to a recently published study, cannabis sugar leaves demonstrate promising antimicrobial effects against several ...