A Cas protein binding can't be too transient, according to Porter Hall, a biophysics doctoral candidate in the Wang Lab and the lead author of the publication.

“We describe a minimal functional CRISPR-Cas system, comprising a single ~70-kilodalton protein, CasΦ, and a CRISPR array, encoded exclusively in the genomes of huge bacteriophages,” the ...

"This study shows that this virus-encoded CRISPR-Cas protein is actually very good at what it does, but it is a lot smaller, about half the size of Cas9," said Doudna. What Comes Next? The message of ...

Hypercompact Cas protein should allow easier viral delivery of gene editors Date: July 16, 2020 Source: University of California - Berkeley Summary: ...

NSP and Cas family proteins form multidomain signaling platforms that integrate signals to mediate cell migration and invasion. Structural analyses show that the C-terminal domain of human NSP ...

We showed that the Cas protein forms a binary complex with guide RNA and remains bound when it interacts with target DNA – subsequently forming a ternary complex. Overall, our results reveal the ...

Now scientists have identified a new kind of Cas protein in bacteriophages. These new Cas enzymes, called CasΦ (or Cas-phi, because Φ is used to denote bacteriophages), are smaller than the ones that ...

Tiny New CRISPR Protein Could Make Human Gene-Hacking Less Risky Step aside, CRISPR-Cas9. / Enhanced Humans / CRISPR / CRISPR Cas 9 / Crispr Casx ...

A Cas protein binding can't be too transient, according to Porter Hall, a biophysics doctoral candidate in the Wang Lab and the lead author of the publication.

UC Berkeley scientists have now discovered a hypercompact Cas protein, CasΦ, that should work better. It is half the size of Cas9 and apparently evolved inside a bacteriophage, yet efficiently ...