In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...

ABOUT CARVYKTI® (CILTACABTAGENE AUTOLEUCEL; CILTA-CEL) ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

The EC has granted conditional marketing approval to Regeneron Pharmaceuticals’ bispecific antibody Lynozyfic for treating multiple myeloma.

The insights from computational models have greatly improved our understanding of the mechanisms that control T-cell activation. In this review, we focus on the use of ordinary differential ...

which promote greater expansion and persistence of T cells. However, the increased activation and persistence can also lead to higher rates of T cell exhaustion, potentially reducing their long-term ...

Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

and LAG-3), increased expression of activation markers (eg, CD38 and CD25), and reduced expression of cytotoxic activity markers (eg, granzyme B). 18,51,54 Reflecting better T-cell fitness, patients ...

T cell activation, a process requiring three “signals,” is required for optimal anti-tumor immunity. T cells, immune cells generated in the thymus, have a programmed affinity for a specific particle ...

Here, T cells play a special role. After activation, they can systematically kill off target cells that have degenerated or are infected with a virus. The antigenic MHC-I molecules remain stable ...

This simultaneous binding results in the recruitment of T cells to the tumour, followed by T-cell activation and degranulation ... to the introduction of proteasome inhibitors, IMiDs, and ...