“When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8+ T cells,” Grimson said. Meanwhile, in Hanson’s lab, ...

If CD8+ T cell exhaustion can be reversed, the next question is whether such reversal actually benefits a patient, as exhaustion can have protective qualities.

"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...

This altered metabolism resulted in increased levels of lipid peroxides and potentiated the metabolic and functional exhaustion of CD8 + T cells in cancer. Chronic type I interferon signaling ...

Silencing KLF2 drove the CD8 T cells along a different path, directing them away from becoming killer cells and toward a ...

“T cell exhaustion is a specific CD8 + T cell differentiation state that is induced by chronic exposure to antigen such as from chronic viral infections or cancer,” the investigators wrot ...

Cannabis and its synthetic cannabinoids have been studied for medicinal properties across multiple d Researchers evaluated the effect of cannabis on inflammation, immune function, and the HIV ...

Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...